aaron ciechanover

Aaron Ciechanover was born in 1947 in Haifa, Israel and is currently an outstanding research professor at the Israel Institute of Technology in Haifa. He obtained a Master of Medicine degree from Hebrew University in Jerusalem in 1971 and a Doctor of Medicine degree in 1973. From 1973 to 1976, he entered the military and served as a military doctor. He then continued his academic career and obtained a PhD in Biological Sciences from the Medical Department of the Israel Institute of Technology in 1982. Here, as a graduate, he and Dr. Avram Hershko, as well as Dr. Irwin Rose from the Fox Chase Cancer Center in Philadelphia, USA, jointly discovered the covalent binding phenomenon between ubiquitin proteins and their corresponding target proteins during degradation. They cracked down on the principle of this binding, elaborated on the general protein lysis function of this mechanism, and also proposed a model to determine the occurrence of a specific protease based on this change. As a postdoctoral researcher, he and Dr. Harvey Lodish of the Massachusetts Institute of Technology continued their research on the ubiquitin system and made other important discoveries. During this period, he gradually realized that ubiquitin mediated protein hydrolysis plays an important role in many cellular physiological processes, and deviations in this system may form the pathogenesis of various diseases, including certain malignant tumors and neurodegenerative diseases. Later, the system became an important platform for drug development. Aaron Chehanovo has won multiple awards, including the 2000 Abelesk Prize, the 2003 Israel Prize, and the 2004 Nobel Prize in Chemistry; Obtained jointly with Hershko and Rose. Chehanovo is also a member of many societies, including the Israel Academy of Sciences and Humanities, foreign members of the American Academy of Arts and Sciences, the American Philosophical Society, the National Academy of Sciences, foreign associate members of the National Academy of Medicine, the Vatican Academy of Sciences, and CAS of the Chinese Academy of Sciences; Foreign members and foreign members of the Russian Academy of Sciences.